Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04370-1
To inform precision management of obesity, this study developed and externally validated a parsimonious model (OBSCORE) that accurately predicts the risk of 18 obesity-related complications. This was achieved by integrating thousands of clinical, molecular and other health-related characteristics assessed in 200,000 individuals with overweight or obesity within a machine-learning framework.
