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Nature Medicine, Published online: 19 May 2026; doi:10.1038/s41591-026-04398-3

In a prospective cohort of 166 participants (and in a 63-participant validation cohort), dermal α-synuclein and 4-repeat tau seed amplification, combined with serum neurofilament light chain assays, were able to identify parkinsonian syndromes.

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