Nature Medicine, Published online: 02 September 2026; doi:10.1038/s41591-026-04604-2
Preeclampsia and fetal growth restriction (FGR) are major causes of fetal morbidity and mortality globally. Both conditions are associated with impaired invasion of the uterus by trophoblasts. We found that lower maternal serum levels of isthmin 2 (ISM2) in early pregnancy are predictive of preeclampsia and FGR and that ISM2 is essential for trophoblast invasion.
