Nature Medicine, Published online: 03 September 2026; doi:10.1038/s41591-026-04682-2
A large, multimodal molecular characterization of the adult human hippocampus provides evidence for sustained neurogenesis and identifies a stalled neurogenic process in major depressive disorder (MDD). Cell- and circuit-specific genetic, epigenetic, stress, immune, metabolic and synaptic mechanisms are identified that underlie impaired hippocampal plasticity, providing a framework for disease subtyping and therapeutic development.
