Nature Medicine, Published online: 23 September 2026; doi:10.1038/s41591-026-04632-y
A multimodal analysis of patients with multiple myeloma who developed enterocolitis following BCMA CAR-T cell treatment shows that CAR-T cell-associated enterocolitis is not defined exclusively by plasma cell and B cell depletion, but is associated with expansion of cytotoxic CAR-T cells and coordinated dysregulation across various intestinal compartments, and also supports JAK inhibitors as a potential treatment option.
