Nature Medicine, Published online: 05 November 2026; doi:10.1038/s41591-026-04744-5
Fecal shotgun metagenomics from 6,803 adults in the Japanese 4D cohort and microbiome-based prediction scores validated across 13 independent and geographically diverse cohorts revealed two opposing microbiome-mediated axes linking lifestyle to health and 15 diseases.
