Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04625-x In a prospective study involving 1,785 individuals from four countries, the PANXEON exosome-based biomarker, combined with carbohydrate antigen 19-9 levels, achieves high sensitivity for the detection of early-stage pancreatic cancer. Read More

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04636-8 In this single-arm phase 1 trial, an AAV gene therapy carrying the Padua variant of factor IX was well tolerated in 11 adolescents with hemophilia B and led to reductions in annualized bleeding rate. Read More

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04662-6 Sex-specific biological aging clocks across multiple organs and molecular systems show that female and male aging patterns can differ in organ-specific, disease-relevant ways. Read More

How moving randomness outside the computation graph turns noisy gradient estimators into low-variance, differentiable ones The post Reparameterization Tricks: Variance Reduction by Smarter Gradients appeared first on Towards Data Science. Read More