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Nature Medicine, Published online: 14 September 2026; doi:10.1038/s41591-026-04622-0 In this Comment, we argue for a global health system that recognizes and supports countries as the primary agents of action, oriented around global public goods and collective action, and served by a leaner set of global and regional institutions. We present a potential vision for the …

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Nature Medicine, Published online: 14 September 2026; doi:10.1038/s41591-026-04676-0 Whole-genome sequencing of 7,851 parent–offspring families enabled the identification of parent-of-origin and post-zygotic de novo mutations that were associated with distinct procedures of assisted reproductive technology (ART), independently of parental age at conception. Increased paternal mutational burden statistically mediates the effects of advanced parental age and ART …

Science News

Nature Medicine, Published online: 13 September 2026; doi:10.1038/s41591-026-04488-2 In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making. Read More