Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04327-4 In this phase 2 trial, combination treatment with elraglusib, a cell-permeable ATP-competitive inhibitor of glycogen synthase kinase-3β, and gemcitabine plus nab-paclitaxel (GnP), in patients with previously untreated metastatic pancreatic ductal adenocarcinoma led to prolonged overall survival compared with GnP only. Read More
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04317-6 A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness following treatment. Read More
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04360-3 Antibiotic use over the past 8 years was associated with alterations in the gut microbiome composition in 14,979 individuals. These analyses integrated data from the Swedish National Prescribed Drug Register and stool metagenomic profiles. Alterations were found even after a single antibiotic course and varied markedly across …
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04390-x Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions Read More
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04314-9 Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus. Read More